CicakmanHairi (Saiful Apek) is a loser who lives in Metrofulus. While working in the lab, he accidentally drinks coffee that has been contaminated by a virus-infected gecko. He soon finds himself doing the most insane things, such as sticking to walls, making chirping cicak noises and adding bugs to his menu. He turns to his best friend and apartment mate, Danny (Yusry Abdul Halim), and begs him to find the reason behind his strange antics. Meanwhile, the people of Metrofulus are constantly being infected by new strains of viruses, and the only cure seems to come only from Professor Klon's (Aznil Nawawi) lab. Suspecting something amiss, Hairi and Danny launch their own investigation and discover that Professor Klon is not only the creator of such viruses, but also has a more sinister plan up his sleeve, backed by his business partners, the Ginger Boys Ramlie and AC Mizal, who first tend to take revenge on Professor Klon's failed experiment on them; making their senses turn abnormal. Lukisan Ratu KidulDimas and Satria Soedibyo actually has many questions when their father died: their grandfather; Rusdi Soedibyo, is a famous painter in the 80s, the death of their mother who was never told, the house that is now suddenly passed on to them, also about a painting hidden in the house. Dimas invites his wife and child, Astrid and Sandra, to visit the house to find answers. Satria finds various items that make him sure, that the house might have been occupied by them as a child. In that house, when the night comes, appeares the figure of a woman dressed in Javanese nobility, who haunting Satria. Dimas actually want to sell the house to a collector who believes that there is a very high value painting in the house. The painting is later discovered by Sandra. The Queen of South painting by the grandfather was the source of the Soedibyo family's disaster for decades. The figure behind the painting now threatens the safety of Dimas, Satria, Astrid and Sandra.