CicakmanHairi (Saiful Apek) is a loser who lives in Metrofulus. While working in the lab, he accidentally drinks coffee that has been contaminated by a virus-infected gecko. He soon finds himself doing the most insane things, such as sticking to walls, making chirping cicak noises and adding bugs to his menu. He turns to his best friend and apartment mate, Danny (Yusry Abdul Halim), and begs him to find the reason behind his strange antics. Meanwhile, the people of Metrofulus are constantly being infected by new strains of viruses, and the only cure seems to come only from Professor Klon's (Aznil Nawawi) lab. Suspecting something amiss, Hairi and Danny launch their own investigation and discover that Professor Klon is not only the creator of such viruses, but also has a more sinister plan up his sleeve, backed by his business partners, the Ginger Boys Ramlie and AC Mizal, who first tend to take revenge on Professor Klon's failed experiment on them; making their senses turn abnormal. Arus MerahSaudara Risham, Dato Saidi, dibunuh. Risham tahu bahwa Marwan yang membunuhnya, lalu mencarinya. Dia menggunakan Masrina, saudari Marwan, untuk memancing Marwan. Risham ingin membunuh Marwan, tetapi dia ingin mengetahui alasan di balik pembunuhan saudaranya, temannya, Falak, dan bahkan staf saudaranya. Semua itu karena perbuatan Dato Saidi 15 tahun lalu. Mulai hari itu, Marwan berjanji untuk membalas dendam.